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ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance. Here we show that ITK, an important modulator of TCR signal...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5482062/ https://ncbi.nlm.nih.gov/pubmed/28635957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15871 |
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