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Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
Synaptic transmission requires a stable pool of release-ready (primed) vesicles. Here we show that two molecules involved in SNARE-complex assembly, Munc13-1 and Munc18-1, together stabilize release-ready vesicles by preventing de-priming. Replacing neuronal Munc18-1 by a non-neuronal isoform Munc18...
Enregistré dans:
| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5482055/ https://ncbi.nlm.nih.gov/pubmed/28635948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15915 |
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