Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Synaptic transmission requires a stable pool of release-ready (primed) vesicles. Here we show that two molecules involved in SNARE-complex assembly, Munc13-1 and Munc18-1, together stabilize release-ready vesicles by preventing de-priming. Replacing neuronal Munc18-1 by a non-neuronal isoform Munc18...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: He, Enqi, Wierda, Keimpe, van Westen, Rhode, Broeke, Jurjen H., Toonen, Ruud F., Cornelisse, L. Niels, Verhage, Matthijs
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482055/
https://ncbi.nlm.nih.gov/pubmed/28635948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15915
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi