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Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

Prompt recovery after intense activity is an essential feature of most mammalian synapses. Here we show that synapses with reduced expression of the presynaptic gene munc18-1 suffer from increased depression during intense stimulation at glutamatergic, GABAergic, and neuromuscular synapses. Converse...

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Détails bibliographiques
Auteurs principaux: Toonen, Ruud F. G., Wierda, Keimpe, Sons, Michèle S., de Wit, Heidi, Cornelisse, L. Niels, Brussaard, Arjen, Plomp, Jaap J., Verhage, Matthijs
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2006
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838751/
https://ncbi.nlm.nih.gov/pubmed/17110441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608507103
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