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Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

Prompt recovery after intense activity is an essential feature of most mammalian synapses. Here we show that synapses with reduced expression of the presynaptic gene munc18-1 suffer from increased depression during intense stimulation at glutamatergic, GABAergic, and neuromuscular synapses. Converse...

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Bibliografische gegevens
Hoofdauteurs: Toonen, Ruud F. G., Wierda, Keimpe, Sons, Michèle S., de Wit, Heidi, Cornelisse, L. Niels, Brussaard, Arjen, Plomp, Jaap J., Verhage, Matthijs
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838751/
https://ncbi.nlm.nih.gov/pubmed/17110441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608507103
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