Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

The binding of antigen to the multicomponent T-cell receptor (TCR) activates several signal transduction pathways via coupling mechanisms that are poorly understood. One event that follows antigen receptor engagement is the activation of inositol phospholipid-specific phospholipase C (PLC). TCR acti...

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Dettagli Bibliografici
Autori principali: June, C H, Fletcher, M C, Ledbetter, J A, Schieven, G L, Siegel, J N, Phillips, A F, Samelson, L E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC54820/
https://ncbi.nlm.nih.gov/pubmed/2217205
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