Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.

Early events in both T-cell receptor (CD3)- and CD4-induced signal transduction pathways include tyrosine phosphorylation of protein substrates, the generation of phosphatidylinositol-phosphate breakdown products, and the mobilization of intracellular Ca2+. Oxidative stress in T cells mediated by su...

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Bibliographic Details
Main Authors: Kanner, S B, Kavanagh, T J, Grossmann, A, Hu, S L, Bolen, J B, Rabinovitch, P S, Ledbetter, J A
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC48224/
https://ncbi.nlm.nih.gov/pubmed/1370350
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