Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

The binding of antigen to the multicomponent T-cell receptor (TCR) activates several signal transduction pathways via coupling mechanisms that are poorly understood. One event that follows antigen receptor engagement is the activation of inositol phospholipid-specific phospholipase C (PLC). TCR acti...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	June, C H, Fletcher, M C, Ledbetter, J A, Schieven, G L, Siegel, J N, Phillips, A F, Samelson, L E
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1990
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2217205/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.19.7722
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