Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

BACKGROUND: Perturbation of commensal intestinal microbiota has been associated with several autoimmune diseases. Mice deficient in interleukin-1 receptor antagonist (Il1rn (−/−) mice) spontaneously develop autoimmune arthritis and are susceptible to other autoimmune diseases such as psoriasis, diab...

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Detalhes bibliográficos
Publicado no:Microbiome
Main Authors: Rogier, Rebecca, Ederveen, Thomas H. A., Boekhorst, Jos, Wopereis, Harm, Scher, Jose U., Manasson, Julia, Frambach, Sanne J. C. M., Knol, Jan, Garssen, Johan, van der Kraan, Peter M., Koenders, Marije I., van den Berg, Wim B., van Hijum, Sacha A. F. T., Abdollahi-Roodsaz, Shahla
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481968/
https://ncbi.nlm.nih.gov/pubmed/28645307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-017-0278-2
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