Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

BACKGROUND: Perturbation of commensal intestinal microbiota has been associated with several autoimmune diseases. Mice deficient in interleukin-1 receptor antagonist (Il1rn (−/−) mice) spontaneously develop autoimmune arthritis and are susceptible to other autoimmune diseases such as psoriasis, diab...

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Pubblicato in:Microbiome
Autori principali: Rogier, Rebecca, Ederveen, Thomas H. A., Boekhorst, Jos, Wopereis, Harm, Scher, Jose U., Manasson, Julia, Frambach, Sanne J. C. M., Knol, Jan, Garssen, Johan, van der Kraan, Peter M., Koenders, Marije I., van den Berg, Wim B., van Hijum, Sacha A. F. T., Abdollahi-Roodsaz, Shahla
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481968/
https://ncbi.nlm.nih.gov/pubmed/28645307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-017-0278-2
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