VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2

The von Hippel-Lindau (VHL) is deficient in ∼70% of clear-cell renal cell carcinomas (ccRCC), which contributes to the carcinogenesis and drug resistance of ccRCC. Here we show that VHL-deficient ccRCC cells present enhanced cytotoxicity of anthracyclines in a hypoxia-inducible factor-independent ma...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Gao, Yao-Hui, Wu, Zhao-Xia, Xie, Li-Qi, Li, Cai-Xia, Mao, Yu-Qin, Duan, Yan-Tao, Han, Bing, Han, San-Feng, Yu, Yun, Lu, Hao-Jie, Yang, Peng-Yuan, Xu, Tian-Rui, Xia, Jing-Lin, Chen, Guo-Qiang, Wang, Li-Shun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481740/
https://ncbi.nlm.nih.gov/pubmed/28643803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15337
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