Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach

BACKGROUND AND PURPOSE: With the emergence of extensively drug‐resistant tuberculosis, there is a need for new anti‐tubercular drugs that work through novel mechanisms of action. The meta cleavage product hydrolase, HsaD, has been demonstrated to be critical for the survival of Mycobacterium tubercu...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ryan, Ali, Polycarpou, Elena, Lack, Nathan A, Evangelopoulos, Dimitrios, Sieg, Christian, Halman, Alice, Bhakta, Sanjib, Eleftheriadou, Olga, McHugh, Timothy D, Keany, Sebastian, Lowe, Edward D, Ballet, Romain, Abuhammad, Areej, Jacobs, William R, Ciulli, Alessio, Sim, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Themed Section: Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481647/
https://ncbi.nlm.nih.gov/pubmed/28380256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13810
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