The isoprenoid derivative N(6)‐benzyladenosine CM223 exerts antitumor effects in glioma patient‐derived primary cells through the mevalonate pathway

BACKGROUND AND PURPOSE: N(6)‐Isopentenyladenosine (i6A) is a modified nucleoside exerting in vitro and in vivo antiproliferative effects. We previously demonstrated that the actions of i6A correlate with the expression and activity of farnesyl pyrophosphate synthase (FPPS), a key enzyme involved in...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Ciaglia, Elena, Grimaldi, Manuela, Abate, Mario, Scrima, Mario, Rodriquez, Manuela, Laezza, Chiara, Ranieri, Roberta, Pisanti, Simona, Ciuffreda, Pierangela, Manera, Clementina, Gazzerro, Patrizia, D'Ursi, Anna Maria, Bifulco, Maurizio
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481646/
https://ncbi.nlm.nih.gov/pubmed/28419419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13824
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