Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain

Recent advances in developing opioid treatments for pain with reduced side effects have focused on the signaling cascades of the μ-opioid receptor (MOR). However, few such signaling targets have been identified for exploitation. To address this need, we explored the role of heat-shock protein 90 (Hs...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lei, Wei, Mullen, Nathan, McCarthy, Sarah, Brann, Courtney, Richard, Philomena, Cormier, James, Edwards, Katie, Bilsky, Edward J., Streicher, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481554/
https://ncbi.nlm.nih.gov/pubmed/28450396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769489
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