Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HSCs) activation in vitro and liver fibrosis progression in vivo. FAK activation is ass...

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Pubblicato in:Sci Rep
Autori principali: Zhao, Xue-Ke, Yu, Lei, Cheng, Ming-Liang, Che, Pulin, Lu, Yin-Ying, Zhang, Quan, Mu, Mao, Li, Hong, Zhu, Li-Li, Zhu, Juan-Juan, Hu, Meng, Li, Po, Liang, Yue-Dong, Luo, Xin-Hua, Cheng, Yi-Ju, Xu, Zhi-Xiang, Ding, Qiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481439/
https://ncbi.nlm.nih.gov/pubmed/28642549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04317-0
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