In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking

ABSTRACT: Coagulation Factor Xa (FXa) is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways. The inhibition of FXa is an effective approach against thrombotic diseases. In the present study, a specific strategy is reported to discover 10 novel FXa inhibito...

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Vydáno v:Nat Prod Bioprospect
Hlavní autoři: Pu, Yinglan, Liu, Hui, Zhou, Yeheng, Peng, Jiale, Li, Yaping, Li, Penghua, Li, Yingying, Liu, Xingyong, Zhang, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Singapore 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481271/
https://ncbi.nlm.nih.gov/pubmed/28577290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13659-017-0126-x
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