Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles

Silica nanoparticles with iron on their surface cause the production of oxidants and stimulate an inflammatory response in macrophages. Nuclear factor erythroid-derived 2 –like factor 2 (Nrf2) signaling and its regulated antioxidant genes play critical roles in maintaining redox homeostasis. In this...

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Gepubliceerd in:Free Radic Biol Med
Hoofdauteurs: Zhang, Hongqiao, Zhou, Lulu, Yuen, Jenay, Birkner, Nancy, Leppert, Valerie, O’Day, Peggy A., Forman, Henry Jay
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480609/
https://ncbi.nlm.nih.gov/pubmed/28389405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.04.002
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