Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by development of pathogenic humoral and cellular autoimmunity to citrullinated proteins. Neutrophil extracellular traps (NETs) are a source of citrullinated autoantigens and activate RA synovial fibroblasts (FLS), cells c...

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Vydáno v:Sci Immunol
Hlavní autoři: Carmona-Rivera, Carmelo, Carlucci, Philip M., Moore, Erica, Lingampalli, Nithya, Uchtenhagen, Hannes, James, Eddie, Liu, Yudong, Bicker, Kevin L., Wahamaa, Heidi, Hoffmann, Victoria, Catrina, Anca Irinel, Thompson, PaulR., Buckner, Jane H., Robinson, William H., Fox, David A., Kaplan, Mariana J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479641/
https://ncbi.nlm.nih.gov/pubmed/28649674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aag3358
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