A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways

Apoptotic stimuli augment intracellular calcium concentration through inositol 1,4,5-trisphosphate receptors (IP(3)R) on endoplasmic reticulum calcium stores. We previously discovered an apoptotic cascade wherein cytochrome c binds to IP(3)R early in apoptosis, resulting in dysregulated calcium rele...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Boehning, Darren, van Rossum, Damian B., Patterson, Randen L., Snyder, Solomon H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2005
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547891/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15665074/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409650102
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