Receptor editing in peripheral B cell tolerance

Receptor editing or secondary Ig gene rearrangement occurs in immature, autoreactive B cells to maintain self-tolerance. Here we show that nonspontaneously autoimmune mice immunized with a peptide mimetope of DNA develop peptide- and DNA-reactive antibodies. Antigen-specific B cells display a follic...

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Bibliografiske detaljer
Main Authors: Rice, Jeffrey S., Newman, Jeffrey, Wang, Chuansheng, Michael, Daniel J., Diamond, Betty
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC547880/
https://ncbi.nlm.nih.gov/pubmed/15659547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409217102
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