Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo

Runx transcription factors comprise a family of proteins that are essential for organogenesis. A unique nuclear matrix-targeting signal in the C terminus directs these factors to their appropriate subnuclear domains. At these sites, they interact with coregulatory proteins and target genes. We have...

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Главные авторы: Javed, Amjad, Barnes, George L., Pratap, Jitesh, Antkowiak, Tomasz, Gerstenfeld, Louis C., van Wijnen, Andre J., Stein, Janet L., Lian, Jane B., Stein, Gary S.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC547873/
https://ncbi.nlm.nih.gov/pubmed/15665096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409121102
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