Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

Myelin basic protein (MBP) is a major candidate autoantigen in multiple sclerosis (MS). Its immunodominant epitope, MBP 85–99, forms a complex with human leukocyte antigen (HLA)-DR2 with which multiple sclerosis is genetically associated. Copolymer 1 (Copaxone), a random amino acid copolymer [poly (...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Fridkis-Hareli, Masha, Kuchroo, Vijay K., Strominger, Jack L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547868/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15665083/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409022102
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