Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

Myelin basic protein (MBP) is a major candidate autoantigen in multiple sclerosis (MS). Its immunodominant epitope, MBP 85–99, forms a complex with human leukocyte antigen (HLA)-DR2 with which multiple sclerosis is genetically associated. Copolymer 1 (Copaxone), a random amino acid copolymer [poly (...

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Hlavní autoři: Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Fridkis-Hareli, Masha, Kuchroo, Vijay K., Strominger, Jack L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC547868/
https://ncbi.nlm.nih.gov/pubmed/15665083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409022102
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