Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells

A humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) protein associated with multiple sclerosis (MS) and the myelin basic protein (MBP) 85–99-specific HLA-DR2-restricted T cell receptor from an MS patient has been used to examine the effectiveness of modified amino acid copolymers poly(F,Y,A,K)n an...

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Detalhes bibliográficos
Principais autores: Illés, Zsolt, Stern, Joel N. H., Reddy, Jayagopala, Waldner, Hanspeter, Mycko, Marcin P., Brosnan, Celia F., Ellmerich, Stephan, Altmann, Daniel M., Santambrogio, Laura, Strominger, Jack L., Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC511047/
https://ncbi.nlm.nih.gov/pubmed/15292513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403833101
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