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Structural implications for the formation and function of the complement effector protein iC3b()

Complement-mediated opsonization, phagocytosis, and immune stimulation are critical processes in host defense and homeostasis, with the complement activation fragment iC3b playing a key effector role. To date, however, there is no high-resolution structure of iC3b, and some aspects of its structure-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Papanastasiou, Malvina, Koutsogiannaki, Sophia, Sarigiannis, Yiannis, Geisbrecht, Brian V., Ricklin, Daniel, Lambris, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478675/
https://ncbi.nlm.nih.gov/pubmed/28258193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601864
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