Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease

Recent studies have demonstrated that hyperphosphorylation of tau protein plays a role in neuronal toxicities of α-synuclein (ASYN) in neurodegenerative disease such as familial Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease. Using a transgenic mouse model of Parki...

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Publicado no:Sci Rep
Main Authors: Fang, Fang, Yang, Wanlin, Florio, Jazmin B., Rockenstein, Edward, Spencer, Brian, Orain, Xavier M., Dong, Stephanie X., Li, Huayan, Chen, Xuqiao, Sung, Kijung, Rissman, Robert A., Masliah, Eliezer, Ding, Jianqing, Wu, Chengbiao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478665/
https://ncbi.nlm.nih.gov/pubmed/28634349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04232-4
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