Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling

Cocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. Cyclin-dependent kinase 5 (Cdk5) and its activator p35, proteins involved in phosphorylation of substrates in postmitotic neurons, have been found to be up-regulated after ch...

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Autors principals: Takahashi, Satoru, Ohshima, Toshio, Cho, Andrew, Sreenath, Taduru, Iadarola, Michael J., Pant, Harish C., Kim, Yong, Nairn, Angus C., Brady, Roscoe O., Greengard, Paul, Kulkarni, Ashok B.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC547862/
https://ncbi.nlm.nih.gov/pubmed/15665076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409456102
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