Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling

Cocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. Cyclin-dependent kinase 5 (Cdk5) and its activator p35, proteins involved in phosphorylation of substrates in postmitotic neurons, have been found to be up-regulated after ch...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Takahashi, Satoru, Ohshima, Toshio, Cho, Andrew, Sreenath, Taduru, Iadarola, Michael J., Pant, Harish C., Kim, Yong, Nairn, Angus C., Brady, Roscoe O., Greengard, Paul, Kulkarni, Ashok B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547862/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15665076/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409456102
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