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Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling
Cocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. Cyclin-dependent kinase 5 (Cdk5) and its activator p35, proteins involved in phosphorylation of substrates in postmitotic neurons, have been found to be up-regulated after ch...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC547862/ https://ncbi.nlm.nih.gov/pubmed/15665076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409456102 |
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