Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC®) for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants: 2016 Update

CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic antidepressants (TCAs), with some drugs being affected by CYP2D6 only (e.g., nortriptyline and desipramine) and others by both polymorphic enzymes (e.g., amitriptyline, clomipramine, doxepin, imipramine, and trimi...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Hicks, J. Kevin, Sangkuhl, Katrin, Swen, Jesse J., Ellingrod, Vicki L., Müller, Daniel J., Shimoda, Kazutaka, Bishop, Jeffrey R., Kharasch, Evan D., Skaar, Todd C., Gaedigk, Andrea, Dunnenberger, Henry M., Klein, Teri E., Caudle, Kelly E., Stingl, Julia C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478479/
https://ncbi.nlm.nih.gov/pubmed/27997040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.597
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