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Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams
Peptidoglycan is an essential crosslinked polymer that surrounds bacteria and protects them from osmotic lysis. Beta-lactam antibiotics target the final stages of peptidoglycan biosynthesis by inhibiting the transpeptidases that crosslink glycan strands to complete cell wall assembly. Characterizati...
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| Yayımlandı: | Nat Chem Biol |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5478438/ https://ncbi.nlm.nih.gov/pubmed/28553948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2388 |
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