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Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction

[Image: see text] Penicillin-binding proteins (PBPs) are involved in the synthesis and remodeling of bacterial peptidoglycan (PG). Staphylococcus aureus expresses four PBPs. Genetic studies in S. aureus have implicated PBP4 in the formation of highly cross-linked PG, but biochemical studies have not...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Qiao, Yuan, Lebar, Matthew D., Schirner, Kathrin, Schaefer, Kaitlin, Tsukamoto, Hirokazu, Kahne, Daniel, Walker, Suzanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210121/
https://ncbi.nlm.nih.gov/pubmed/25291014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja508147s
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