Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Steinman, Jonathan B, Santarossa, Cristina C, Miller, Rand M, Yu, Lola S, Serpinskaya, Anna S, Furukawa, Hideki, Morimoto, Sachie, Tanaka, Yuta, Nishitani, Mitsuyoshi, Asano, Moriteru, Zalyte, Ruta, Ondrus, Alison E, Johnson, Alex G, Ye, Fan, Nachury, Maxence V, Fukase, Yoshiyuki, Aso, Kazuyoshi, Foley, Michael A, Gelfand, Vladimir I, Chen, James K, Carter, Andrew P, Kapoor, Tarun M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478271/
https://ncbi.nlm.nih.gov/pubmed/28524820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25174
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