Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

[Image: see text] Cytoplasmic dyneins 1 and 2 are related members of the AAA+ superfamily (ATPases associated with diverse cellular activities) that function as the predominant minus-end-directed microtubule motors in eukaryotic cells. Dynein 1 controls mitotic spindle assembly, organelle movement,...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: See, Stephanie K., Hoogendoorn, Sascha, Chung, Andrew H., Ye, Fan, Steinman, Jonathan B., Sakata-Kato, Tomoyo, Miller, Rand M., Cupido, Tommaso, Zalyte, Ruta, Carter, Andrew P., Nachury, Maxence V., Kapoor, Tarun M., Chen, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715766/
https://ncbi.nlm.nih.gov/pubmed/26555042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00895
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