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Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion
The genetic code in a eukaryotic system has been expanded by the engineering of Escherichia coli tyrosyl-tRNA synthetase (TyrRS) with the Y37V and Q195C mutations (37V195C), which specifically recognize 3-iodo-l-tyrosine rather than l-tyrosine. In the present study, we determined the 3-iodo-l-tyrosi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC547826/ https://ncbi.nlm.nih.gov/pubmed/15671170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407039102 |
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