CRISPR/Cas9 – Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms

Precisely targeted genome editing is highly desired for clinical applications. However, the widely used homology-directed repair (HDR)-based genome editing strategies remain inefficient for certain in vivo applications. We here demonstrate a microhomology-mediated end-joining (MMEJ)-based strategy f...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Yao, Xuan, Wang, Xing, Liu, Junlai, Hu, Xinde, Shi, Linyu, Shen, Xiaowen, Ying, Wenqin, Sun, Xinyao, Wang, Xin, Huang, Pengyu, Yang, Hui
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478232/
https://ncbi.nlm.nih.gov/pubmed/28527830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.05.015
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