Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation

Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a...

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Udgivet i:EBioMedicine
Main Authors: Kobayashi, Shunsuke, Tanaka, Toru, Soeda, Yoshiyuki, Almeida, Osborne F.X., Takashima, Akihiko
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478209/
https://ncbi.nlm.nih.gov/pubmed/28566250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.05.012
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