Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation

Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Kobayashi, Shunsuke, Tanaka, Toru, Soeda, Yoshiyuki, Almeida, Osborne F.X., Takashima, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478209/
https://ncbi.nlm.nih.gov/pubmed/28566250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.05.012
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