IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation

Graft-versus-host disease (GvHD) remains a major cause of transplant-related mortality. Interleukin-2 (IL-2) plus sirolimus (SIR) synergistically reduces acute GvHD in rodents and promotes regulatory T cells. This phase II trial tested the hypothesis that IL-2 would facilitate STAT5 phosphorylation...

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Publié dans:Haematologica
Auteurs principaux: Betts, Brian C., Pidala, Joseph, Kim, Jongphil, Mishra, Asmita, Nishihori, Taiga, Perez, Lia, Ochoa-Bayona, Jose Leonel, Khimani, Farhad, Walton, Kelly, Bookout, Ryan, Nieder, Michael, Khaira, Divis K., Davila, Marco, Alsina, Melissa, Field, Teresa, Ayala, Ernesto, Locke, Frederick L., Riches, Marcie, Kharfan-Dabaja, Mohamed, Fernandez, Hugo, Anasetti, Claudio
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2017
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477614/
https://ncbi.nlm.nih.gov/pubmed/28104702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.153072
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