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Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence

Efforts to recapitulate haematopoiesis, a process guided by spatial and temporal inductive signals, to generate haematopoietic progenitors from human pluripotent stem cells (hPSCs) have focused primarily on exogenous signalling pathway activation or inhibition. Here we show haemogenic niches can be...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Rahman, Nafees, Brauer, Patrick M., Ho, Lilian, Usenko, Tatiana, Tewary, Mukul, Zúñiga-Pflücker, Juan Carlos, Zandstra, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477512/
https://ncbi.nlm.nih.gov/pubmed/28541275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15380
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