MICU1 drives glycolysis and chemoresistance in ovarian cancer

Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca(2+) uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer. We show th...

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Publicat a:Nat Commun
Autors principals: Chakraborty, Prabir K., Mustafi, Soumyajit Banerjee, Xiong, Xunhao, Dwivedi, Shailendra Kumar Dhar, Nesin, Vasyl, Saha, Sounik, Zhang, Min, Dhanasekaran, Danny, Jayaraman, Muralidharan, Mannel, Robert, Moore, Kathleen, McMeekin, Scott, Yang, Da, Zuna, Rosemary, Ding, Kai, Tsiokas, Leonidas, Bhattacharya, Resham, Mukherjee, Priyabrata
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477507/
https://ncbi.nlm.nih.gov/pubmed/28530221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14634
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