MICU1 drives glycolysis and chemoresistance in ovarian cancer

Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca(2+) uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer. We show th...

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Publicado no:Nat Commun
Main Authors: Chakraborty, Prabir K., Mustafi, Soumyajit Banerjee, Xiong, Xunhao, Dwivedi, Shailendra Kumar Dhar, Nesin, Vasyl, Saha, Sounik, Zhang, Min, Dhanasekaran, Danny, Jayaraman, Muralidharan, Mannel, Robert, Moore, Kathleen, McMeekin, Scott, Yang, Da, Zuna, Rosemary, Ding, Kai, Tsiokas, Leonidas, Bhattacharya, Resham, Mukherjee, Priyabrata
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477507/
https://ncbi.nlm.nih.gov/pubmed/28530221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14634
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