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An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

The activity of the human immunodeficiency virus (HIV) protease is essential for processing of the gag-pol precursor proteins and maturation of infectious virions. We have prepared a peptidomimetic inhibitor, U-75875, that inhibited HIV-1 gag-pol protein processing in an essentially irreversible man...

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Bibliografiske detaljer
Main Authors: Ashorn, P, McQuade, T J, Thaisrivongs, S, Tomasselli, A G, Tarpley, W G, Moss, B
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC54769/
https://ncbi.nlm.nih.gov/pubmed/2217178
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