An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

The activity of the human immunodeficiency virus (HIV) protease is essential for processing of the gag-pol precursor proteins and maturation of infectious virions. We have prepared a peptidomimetic inhibitor, U-75875, that inhibited HIV-1 gag-pol protein processing in an essentially irreversible man...

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Detalhes bibliográficos
Main Authors: Ashorn, P, McQuade, T J, Thaisrivongs, S, Tomasselli, A G, Tarpley, W G, Moss, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC54769/
https://ncbi.nlm.nih.gov/pubmed/2217178
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