C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP

Subjects carrying the C2238 variant of the atrial natriuretic peptide (ANP) gene have a higher occurrence of stroke and acute coronary syndrome, suggesting an increased predisposition to acute thrombotic events in these subjects. We evaluated for the first time the direct effects of mutant ANP (C223...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Carnevale, Roberto, Pignatelli, Pasquale, Frati, Giacomo, Nocella, Cristina, Stanzione, Rosita, Pastori, Daniele, Marchitti, Simona, Valenti, Valentina, Santulli, Maria, Barbato, Emanuele, Strisciuglio, Teresa, Schirone, Leonardo, Vecchione, Carmine, Violi, Francesco, Volpe, Massimo, Rubattu, Speranza, Sciarretta, Sebastiano
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476672/
https://ncbi.nlm.nih.gov/pubmed/28630469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03679-9
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki