Large diverse population cohorts of hiPSCs and derived hepatocyte-like cells reveal functional genetic variation at blood lipid-associated loci

Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to generate induced pluripotent stem cells (iPSCs) and hepatocyte-like cells (HLCs) for geno...

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Publicado no:Cell Stem Cell
Main Authors: Pashos, Evanthia E., Park, YoSon, Wang, Xiao, Raghavan, Avanthi, Yang, Wenli, Abbey, Deepti, Peters, Derek T., Arbelaez, Juan, Hernandez, Mayda, Kuperwasser, Nicolas, Li, Wenjun, Lian, Zhaorui, Liu, Ying, Lv, Wenjian, Lytle-Gabbin, Stacey L., Marchadier, Dawn H., Rogov, Peter, Shi, Jianting, Slovik, Katherine J., Stylianou, Ioannis M., Wang, Li, Yan, Ruilan, Zhang, Xiaolan, Kathiresan, Sekar, Duncan, Stephen A., Mikkelsen, Tarjei S., Morrisey, Edward E., Rader, Daniel J., Brown, Christopher D., Musunuru, Kiran
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476422/
https://ncbi.nlm.nih.gov/pubmed/28388432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.017
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