Large diverse population cohorts of hiPSCs and derived hepatocyte-like cells reveal functional genetic variation at blood lipid-associated loci

Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to generate induced pluripotent stem cells (iPSCs) and hepatocyte-like cells (HLCs) for geno...

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Publié dans:Cell Stem Cell
Auteurs principaux: Pashos, Evanthia E., Park, YoSon, Wang, Xiao, Raghavan, Avanthi, Yang, Wenli, Abbey, Deepti, Peters, Derek T., Arbelaez, Juan, Hernandez, Mayda, Kuperwasser, Nicolas, Li, Wenjun, Lian, Zhaorui, Liu, Ying, Lv, Wenjian, Lytle-Gabbin, Stacey L., Marchadier, Dawn H., Rogov, Peter, Shi, Jianting, Slovik, Katherine J., Stylianou, Ioannis M., Wang, Li, Yan, Ruilan, Zhang, Xiaolan, Kathiresan, Sekar, Duncan, Stephen A., Mikkelsen, Tarjei S., Morrisey, Edward E., Rader, Daniel J., Brown, Christopher D., Musunuru, Kiran
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476422/
https://ncbi.nlm.nih.gov/pubmed/28388432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.017
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