Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms

Focal radiotherapy is frequently associated with skeletal damage within the radiation field. Our previous in vitro study showed that activation of Wnt/β-catenin pathway can overcome radiation-induced DNA damage and apoptosis of osteoblastic cells. Neutralization of circulating sclerostin with a mono...

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Pubblicato in:J Bone Miner Res
Autori principali: Chandra, Abhishek, Lin, Tiao, Young, Tiffany, Tong, Wei, Ma, Xiaoyuan, Tseng, Wei-Ju, Kramer, Ina, Kneissel, Michaela, Levine, Michael A, Zhang, Yejia, Cengel, Keith, Liu, X. Sherry, Qin, Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476363/
https://ncbi.nlm.nih.gov/pubmed/27635523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2996
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