Subchondral bone plate sclerosis during late osteoarthritis is caused by loading-induced reduction in Sclerostin

OBJECTIVE: To establish an unbiased 3D approach that quantifies subchondral bone plate (SBP) changes in mouse joints and to investigate the mechanism that mediates SBP sclerosis at a late stage of osteoarthritis (OA). DESIGN: A new microCT protocol was developed to characterize the entire SBP thickn...

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Publicado en:Arthritis Rheumatol
Autores principales: Jia, Haoruo, Ma, Xiaoyuan, Wei, Yulong, Tong, Wei, Tower, Robert J., Chandra, Abhishek, Wang, Luqiang, Sun, Zeyang, Yang, Zhaochun, Badar, Farid, Zhang, Kairui, Tseng, Wei-ju, Kramer, Ina, Kneissel, Michaela, Xia, Yang, Liu, X. Sherry, Wang, James H-C., Han, Lin, Enomoto-Iwamoto, Motomi, Qin, Ling
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788711/
https://ncbi.nlm.nih.gov/pubmed/29024567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40351
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