Blood stage malaria disrupts humoral immunity to the pre-erythrocytic stage circumsporozoite protein

Many current malaria vaccines target the pre-erythrocytic stage of infection in the liver. However, in malaria endemic regions, increased blood stage exposure is associated with decreased vaccine efficacy, thereby challenging current vaccine efforts. We hypothesized that pre-erythrocytic humoral imm...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Keitany, Gladys J., Kim, Karen S., Krishnamurty, Akshay T., Hondowicz, Brian D., Hahn, William, Dambrauskas, Nicholas, Sather, Noah D., Vaughan, Ashley M., Kappe, Stefan H.I., Pepper, Marion
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476299/
https://ncbi.nlm.nih.gov/pubmed/28009289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.060
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