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Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown
BACKGROUND: Deimination (also known as citrullination), the conversion of arginine in a protein to citrulline, is catalyzed by a family of enzymes called peptidyl-arginine deiminases (PADs). Three PADs are expressed in the epidermis, one of their targets being filaggrin. Filaggrin plays a central ro...
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| Udgivet i: | J Dermatol Sci |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5476296/ https://ncbi.nlm.nih.gov/pubmed/28242341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2017.02.280 |
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