Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown

BACKGROUND: Deimination (also known as citrullination), the conversion of arginine in a protein to citrulline, is catalyzed by a family of enzymes called peptidyl-arginine deiminases (PADs). Three PADs are expressed in the epidermis, one of their targets being filaggrin. Filaggrin plays a central ro...

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Bibliographic Details
Published in:J Dermatol Sci
Main Authors: Cau, Laura, Pendaries, Valérie, Lhuillier, Emeline, Thompson, Paul R, Serre, Guy, Takahara, Hidenari, Méchin, Marie-Claire, Simon, Michel
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476296/
https://ncbi.nlm.nih.gov/pubmed/28242341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2017.02.280
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