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Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice

Lupus is characterized by a loss of B cell tolerance leading to autoantibody production. In this study, we explored the mechanisms underlying this loss of tolerance using B6 congenic mice with an interval from New Zealand Black chromosome 1 (denoted c1(96–100)) sufficient for anti-nuclear antibody p...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Chang, Nan-Hua, Manion, Kieran P., Loh, Christina, Pau, Evelyn, Baglaenko, Yuriy, Wither, Joan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476272/
https://ncbi.nlm.nih.gov/pubmed/28628673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179506
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